Developing scalable cell replacement therapies for the world

Eyestem is a cell therapy company founded by a top-class management team consisting of clinical trial, cell therapy and ophthalmology experts. It also boasts a world class advisory board and we have built collaborations with pioneers and leaders in the space. Our long-term vision is to create a global and scalable cell therapy platform to treat incurable diseases. We are developing a cell therapy platform to produce consistent, quality products over the next few years, concentrating on in vitro efficacy and safety.

We are also establishing processes for manufacturing and controls and instituting GMP manufacturing and GLP studies to cater to market needs worldwide. Our lead product out of the platform is EyecyteRPE aimed at treating Dry AMD (Age-related Macular Degeneration). Dry AMD is the largest cause of incurable blindness in people above 60 and affects roughly 170 million people worldwide. We are currently targeting phase-one trials for EyecyteRPE in the later half of 2020.

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Recent Scientific Papers

Surendran H, Nandakumar S, Konala…

Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration

 Stem Cell Res Ther. 2021; 12: 70. doi: 10.1186/s13287-021-02134-x

Surendran H, Nandakumar S, Pal…

Human Induced Pluripotent Stem Cell-Derived Lung Epithelial System for SARS-CoV-2 Infection Modeling and Its Potential in Drug Repurposing

 Stem Cells Dev . 2020 Sep 18. doi: 10.1089/scd.2020.0152

Pal R, Surendran H, Nandakumar…

Transplantation of retinal pigment epithelium (RPE) and photoreceptor progenitors (PRP) generated through a xeno-free unified protocol showed improved visual sensitivity in two rodent models

 Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2290.

Konala VBR, Nandakumar S, Battu…

Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations

 Stem Cell Res . 2020 May;45:101757. doi: 10.1016/j.scr.2020.101757.

Battu R, Mallipatna A, Elackatt NJ, Schouten JSAG,

Webers Challenges of managing retinal dystrophies: an experience from south India. Ophthalmic Genetics.

2018. 39(1): 1-3.

Surendran H, Rathod RR. Pal R.

Generation of transplantable Retinal Pigmented Epithelial (RPE) cells for treatment of Age-related Macular Degeneration (AMD

2018. Meth Mol Biol. (Accepted).

Battu R, Mohan A, Khanna A, Kumar A, Shetty R

Retinal oxygen saturation in Retinitis Pigmentosa and macular dystrophies in Asian Indian eyes. Invest Ophthalmol Vis Sci. 2015.

56(5): 2798-802.

Battu R, Khanna A, Hegde B, Berendschot TT, Grover G, Schouten JS.

Correlation of Structure and Function of the Macula in patients with Retinitis Pigmentosa. Eye (Lond).

2015. 29(7): 895-901.
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Eyestem
Eyestem@EyestemResearch·
19 Jan

Delighted to share that our paper describing a unified, GMPable protocol to simultaneously generate retinal pigment epithelium and photoreceptors is out. This represents the pinnacle of our research (so far!) https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02134-x

Twitter 1351540998535434240
Eyestem@EyestemResearch·
8 Jan

We announce the second round of funding for EyecyteRPE to treat Dry AMD. Especially pleased by the support from our global investors and the addition of Kotak Private Equity-the largest and most sophisticated life sci investor in India- as a new investor https://www.linkedin.com/posts/eyestem-research_eyestem-funding-news-activity-6753302430097788929-PWsi

Twitter 1347541687988412421

Career Openings

Junior / Senior Research Fellow

Project: Chemistry, manufacturing and control (CMC) of induced pluripotent stem cells-derived retinal pigment epithelial (RPE) cells for the treatment of age related macular degeneration

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