Eyestem research is published in reputed scientific journals worldwide

Recent Publications

Soundararajan L, Surendran H, Patlolla N, Battu R, Stoddard J, Arrizabalaga S, Liu Z, Lingam G, Su X, Ryals RC, Pal R.

Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval.

19 April 2025

Surendran H, Battu R, Gopurappilly R, Vishnuprasad CN, Pal R.

Generation of a human induced pluripotent stem cell (iPSC) line ERPLi004-A from an Alpha-1 Antitrypsin Deficiency (AATD) patient with SERPINA1 mutation

25 January 2025

Subramani J, Patlolla N, Battu R, Saiyed T, Pal R.

Generation and characterisation of retinal pigment epithelium (RPE) from patient iPSC line to model Oculocutaneous Albinism (OCA)1A disease.
J Biosci 2024; 49:21.

12 October 2023

Surendran H, Soundarajan L, Janavi S, Stoddard J, Tchetter W, Reynaga R, Ryals R, Pal R.

An improved protocol for generation and characterization of retinal pigment epithelium (RPE) cells from induced pluripotent stem cells (iPSC). STAR Protoc 2022. 3(4):101803.

11 November 2022

Harshini Surendran, Saurabh Kumar, Swathi Narasimhaiah, Anuradha Ananthamurthy, PS Varghese, George A. D'Souza, Guruprasad Medigeshi, Rajarshi Pal

SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways

23 April 2022

Konala VBR, Nandakumar S, Surendran H, Datar S, Bhonde R, Pal R

Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies.

Toxicol Appl Pharmacol. 2021;433:115792.

Nandakumar S, Shahani P, Datta I, Pal R

Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead?

ACS Chem Neurosci. 2021;12(20):3785-3794.

Pal R

A small-molecule cocktail that beats cellular stress.

Nat Methods. 2021;18(5):457-458

Konala VBR, Nandakumar S, Surendran H, Pal R

Derivation of Induced Pluripotent Stem Cell (iPSC) Lines from Patient-Specific Peripheral Blood Mononuclear Cells (PBMC) Using Episomal Vectors.

Methods Mol Biol. 2021 (Online ahead of print)

Surendran H, Nandakumar S, Konala VBR, Stoddard J, K VM, Upadhyay PK, McGill TJ, Pal R

Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration

Stem Cell Res Ther. 2021; 12: 70. doi: 10.1186/s13287-021-02134-x

Surendran H, Nandakumar S, Pal R

Human Induced Pluripotent Stem Cell-Derived Lung Epithelial System for SARS-CoV-2 Infection Modeling and Its Potential in Drug Repurposing

Stem Cells Dev . 2020 Sep 18. doi: 10.1089/scd.2020.0152

Pal R, Surendran H, Nandakumar S, Konala VBR, Swamy SN, Battu R, McGill TJ, Upadhyay PK

Transplantation of retinal pigment epithelium (RPE) and photoreceptor progenitors (PRP) generated through a xeno-free unified protocol showed improved visual sensitivity in two rodent models

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2290.

Konala VBR, Nandakumar S, Battu R, Pal R

Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations

Stem Cell Res . 2020 May;45:101757. doi: 10.1016/j.scr.2020.101757.

Surendran H, Rathod RJ, Pal R

Generation of transplantable Retinal Pigmented Epithelial (RPE) cells for treatment of Age-related Macular Degeneration (AMD)

Methods Mol Biol. 2018 Jun 13. doi: 10.1007/7651_2018_140.

Battu R, Mallipatna A, Elackatt NJ, Schouten JSAG, Webers CAB

Challenges of managing retinal dystrophies: An experience from South India

Ophthalmic Genet. 2018 Jan-Feb;39(1):1-3.

Rathod R, Surendran H, Battu R, Desai J, Pal R

Induced pluripotent stem cells (iPSC)-derived retinal cells in disease modeling and regenerative medicine

J Chem Neuroanat. 2019 Jan;95:81-88.

May-Simera HL, Wan Q, Jha BS, Hartford J, Khristov V, Dejene R, Chang J, Patnaik S, Lu Q, Banerjee P, Silver J, Insinna-Kettenhofen C, Patel D, Lotfi M, Malicdan M, Hotaling N, Maminishkis A, Sridharan R, Brooks B, Miyagishima K, Gunay-Aygun M, Pal R, Westlake C, Miller S, Sharma R, Bharti K

Primary cilium-mediated Retinal Pigment Epithelium maturation is disrupted in ciliopathy patient cells

Cell Rep. 2018 Jan 2;22(1):189-205.

Surendran H, Rajamoorthy M, Pal R

Differentiating Human Induced Pluripotent Stem Cells (iPSCs) Into Lung Epithelial Cells

Curr Protoc Stem Cell Biol. 2019 Jun;49(1):e86. doi: 10.1002/cpsc.86.

Banerjee P, Surendran H, Bharti K, Morishita K, Varshney A, Pal R

Long noncoding RNA RP11-380D23.2 drives distal-proximal patterning of the lung by regulating PITX2 expression

Stem Cells. 2018 Feb;36(2):218-229.

Louis LK, Gopurappilly R, Surendran H, Dutta S, Pal R

Transcriptional profiling of human neural precursors post alcohol exposure reveals impaired neurogenesis via dysregulation of ERK signaling and miR-145

J Neurochem. 2017 Aug 21. doi: 10.1111/jnc.14155.

Battu R, Jeyabalan N, Murthy P, Reddy KS, Schouten JS, Webers CA

Genetic analysis and clinical phenotype of two Indian families with X-linked choroideremia

Indian J Ophthalmol. 2016 Dec; 64(12): 924–929.

Battu R, Akkali MC, Bhanushali D, Srinivasan P, Shetty R, Berendschot TT, Schouten JS, Webers CA

Adaptive optics imaging of the outer retinal tubules in Bietti's crystalline dystrophy

Eye (Lond). 2016 May;30(5):705-12.

Battu R, Mohan A, Khanna A, Kumar A, Shetty R

Retinal oxygen saturation in retinitis pigmentosa and macular dystrophies in Asian-Indian eyes

Invest Ophthalmol Vis Sci. 2015 May;56(5):2798-802.

Battu R, Khanna A, Hegde B, Berendschot TT, Grover G, Schouten JS

Correlation of structure and function of the macula in patients with retinitis pigmentosa

Eye (Lond). 2015 Jul;29(7):895-901.

Battu R, Verma A, Hariharan R, Krishna S, Kiran R, Jacob J, Ganapathy A, Ramprasad VL, Kumaramanickavel G, Jeyabalan N, Ghosh A

Identification of novel mutations in ABCA4 gene: Clinical and genetic analysis of Indian patients with Stargardt disease

Biomed Res Int. 2015;2015:940864. doi: 10.1155/2015/940864.

Rajasimha HK, Shirol PB, Ramamoorthy P, Hegde M, Barde S, Chandru V, Ravinandan ME, Ramchandran R, Haldar K, Lin JC, Babar IA, Girisha KM, Srinivasan S, Navaneetham D, Battu R, Devarakonda R, Kini U, Vijayachandra K,Verma IC

Organization for rare diseases India (ORDI)-addressing the challenges and opportunities for the Indian rare diseases' community

Genet Res (Camb). 2014 Aug 13;96:e009.doi: 10.1017/S0016672314000111.

Patino LC, Battu R, Ortega-Recalde O, Nallathambi J, Anandula VR, Renukaradhya U, Laissue P

Exome sequencing is an efficient tool for variant late-infantile neuronal ceroid lipofuscinosis molecular diagnosis

PLoS One. 2014 Oct 15;9(10):e109576.doi: 10.1371/journal.pone.0109576.

Battu R, Dabir S, Khanna A, Kumar AK, Roy AS

Adaptive optics imaging of the retina

Indian J Ophthalmol. 2014 Jan; 62(1): 60–65.

Eyestem scientists have published a number of excellent papers in national and international peer-reviewed journals of high repute.

Recent Publications

Soundararajan L, Surendran H, Patlolla N, Battu R, Stoddard J, Arrizabalaga S, Liu Z, Lingam G, Su X, Ryals RC, Pal R.

Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval.

Surendran H, Battu R, Gopurappilly R, Vishnuprasad CN, Pal R.

Generation of a human induced pluripotent stem cell (iPSC) line ERPLi004-A from an Alpha-1 Antitrypsin Deficiency (AATD) patient with SERPINA1 mutation

Subramani J, Patlolla N, Battu R, Saiyed T, Pal R.

Generation and characterisation of retinal pigment epithelium (RPE) from patient iPSC line to model Oculocutaneous Albinism (OCA)1A disease. J Biosci 2024; 49:21.

Surendran H, Soundarajan L, Janavi S, Stoddard J, Tchetter W, Reynaga R, Ryals R, Pal R.

An improved protocol for generation and characterization of retinal pigment epithelium (RPE) cells from induced pluripotent stem cells (iPSC). STAR Protoc 2022. 3(4):101803.

Harshini Surendran, Saurabh Kumar, Swathi Narasimhaiah, Anuradha Ananthamurthy, PS Varghese, George A. D'Souza, Guruprasad Medigeshi, Rajarshi Pal

SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways

Konala VBR, Nandakumar S, Surendran H, Datar S, Bhonde R, Pal R

Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies.

Nandakumar S, Shahani P, Datta I, Pal R

Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead?

Pal R

A small-molecule cocktail that beats cellular stress.

Konala VBR, Nandakumar S, Surendran H, Pal R

Derivation of Induced Pluripotent Stem Cell (iPSC) Lines from Patient-Specific Peripheral Blood Mononuclear Cells (PBMC) Using Episomal Vectors.

Surendran H, Nandakumar S, Konala VBR, Stoddard J, K VM, Upadhyay PK, McGill TJ, Pal R

Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration

Surendran H, Nandakumar S, Pal R

Human Induced Pluripotent Stem Cell-Derived Lung Epithelial System for SARS-CoV-2 Infection Modeling and Its Potential in Drug Repurposing

Pal R, Surendran H, Nandakumar S, Konala VBR, Swamy SN, Battu R, McGill TJ, Upadhyay PK

Transplantation of retinal pigment epithelium (RPE) and photoreceptor progenitors (PRP) generated through a xeno-free unified protocol showed improved visual sensitivity in two rodent models

Konala VBR, Nandakumar S, Battu R, Pal R

Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations

Surendran H, Rathod RJ, Pal R

Generation of transplantable Retinal Pigmented Epithelial (RPE) cells for treatment of Age-related Macular Degeneration (AMD)

Battu R, Mallipatna A, Elackatt NJ, Schouten JSAG, Webers CAB

Challenges of managing retinal dystrophies: An experience from South India

Rathod R, Surendran H, Battu R, Desai J, Pal R

Induced pluripotent stem cells (iPSC)-derived retinal cells in disease modeling and regenerative medicine

May-Simera HL, Wan Q, Jha BS, Hartford J, Khristov V, Dejene R, Chang J, Patnaik S, Lu Q, Banerjee P, Silver J, Insinna-Kettenhofen C, Patel D, Lotfi M, Malicdan M, Hotaling N, Maminishkis A, Sridharan R, Brooks B, Miyagishima K, Gunay-Aygun M, Pal R, Westlake C, Miller S, Sharma R, Bharti K

Primary cilium-mediated Retinal Pigment Epithelium maturation is disrupted in ciliopathy patient cells

Surendran H, Rajamoorthy M, Pal R

Differentiating Human Induced Pluripotent Stem Cells (iPSCs) Into Lung Epithelial Cells

Banerjee P, Surendran H, Bharti K, Morishita K, Varshney A, Pal R

Long noncoding RNA RP11-380D23.2 drives distal-proximal patterning of the lung by regulating PITX2 expression

Louis LK, Gopurappilly R, Surendran H, Dutta S, Pal R

Transcriptional profiling of human neural precursors post alcohol exposure reveals impaired neurogenesis via dysregulation of ERK signaling and miR-145

Battu R, Jeyabalan N, Murthy P, Reddy KS, Schouten JS, Webers CA

Genetic analysis and clinical phenotype of two Indian families with X-linked choroideremia

Battu R, Akkali MC, Bhanushali D, Srinivasan P, Shetty R, Berendschot TT, Schouten JS, Webers CA

Adaptive optics imaging of the outer retinal tubules in Bietti's crystalline dystrophy

Battu R, Mohan A, Khanna A, Kumar A, Shetty R

Retinal oxygen saturation in retinitis pigmentosa and macular dystrophies in Asian-Indian eyes

Battu R, Khanna A, Hegde B, Berendschot TT, Grover G, Schouten JS

Correlation of structure and function of the macula in patients with retinitis pigmentosa

Battu R, Verma A, Hariharan R, Krishna S, Kiran R, Jacob J, Ganapathy A, Ramprasad VL, Kumaramanickavel G, Jeyabalan N, Ghosh A

Identification of novel mutations in ABCA4 gene: Clinical and genetic analysis of Indian patients with Stargardt disease

Rajasimha HK, Shirol PB, Ramamoorthy P, Hegde M, Barde S, Chandru V, Ravinandan ME, Ramchandran R, Haldar K, Lin JC, Babar IA, Girisha KM, Srinivasan S, Navaneetham D, Battu R, Devarakonda R, Kini U, Vijayachandra K,Verma IC

Organization for rare diseases India (ORDI)-addressing the challenges and opportunities for the Indian rare diseases' community

Patino LC, Battu R, Ortega-Recalde O, Nallathambi J, Anandula VR, Renukaradhya U, Laissue P

Exome sequencing is an efficient tool for variant late-infantile neuronal ceroid lipofuscinosis molecular diagnosis

Battu R, Dabir S, Khanna A, Kumar AK, Roy AS

Adaptive optics imaging of the retina

Eyestem scientists have published a number of excellent papers in national and international
peer-reviewed journals of high repute.

Generation and characterisation of retinal pigment epithelium (RPE) from patient iPSC line to model Oculocutaneous Albinism (OCA)1A disease.
J Biosci 2024; 49:21.